Transitions of CDR-L3 Loop Canonical Cluster Conformations on the Micro-to-Millisecond Timescale

Transitions of CDR-L3 Loop Canonical Cluster Conformations on the Micro-to-Millisecond Timescale

Sequence and structural diversity of antibodies are concentrated on six hypervariable loops, also known as the complementarity determining regions (CDRs). Five of six antibody CDR loops presumably adopt a so-called canonical structure out of a limited number of conformations. However, here we show f...

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Bibliographic Details
Main Authors: Monica L. Fernández-Quintero, Barbara A. Math, Johannes R. Loeffler, Klaus R. Liedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
canonical structures
CDR-L3 loop
molecular dynamics simulations
markov-state models
conformational ensemble
antibody structure design
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02652/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02652/full

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