AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation

AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation

Acute pancreatitis (AP) is a highly fatal acute inflammation and is often accompanied by multiple organ dysfunction syndrome (MODS). The liver, one of the most vulnerable extrapancreatic organs in AP, is the major organ involved in the evolution of the disease and correlates strongly with the occurr...

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Bibliographic Details
Main Authors: Lijun Kong, Hewei Zhang, Chaosheng Lu, Keqing Shi, Hongjian Huang, Yushu Zheng, Yongqiang Wang, Dan Wang, Hongwei Wang, Wei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
pancreatitis
liver injury
AMPK
Nrf2
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.724514/full

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