Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growt...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01647-5 |
| id |
doaj-f6e7092fba7f4ee08377d36b15323b24 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang |
| spellingShingle |
Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway Nature Communications |
| author_facet |
Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang |
| author_sort |
Xiaoyu Ma |
| title |
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| title_short |
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| title_full |
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| title_fullStr |
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| title_full_unstemmed |
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| title_sort |
polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-11-01 |
| description |
Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth. |
| url |
https://doi.org/10.1038/s41467-017-01647-5 |
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doaj-f6e7092fba7f4ee08377d36b15323b242021-05-11T07:10:29ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01647-5Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathwayXiaoyu Ma0Lin Wang1De Huang2Yunyan Li3Dongdong Yang4Tingting Li5Fudong Li6Linchong Sun7Haoran Wei8Kun He9Fazhi Yu10Debiao Zhao11Lan Hu12Songge Xing13Zhaoji Liu14Kui Li15Jing Guo16Zhenye Yang17Xin Pan18Ailing Li19Yunyu Shi20Junfeng Wang21Ping Gao22Huafeng Zhang23Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHigh Magnetic Field Laboratory, Chinese Academy of SciencesHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaInstitute of Basic Medical Sciences, National Center of Biomedical AnalysisHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaInstitute of Basic Medical Sciences, National Center of Biomedical AnalysisInstitute of Basic Medical Sciences, National Center of Biomedical AnalysisHefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of ChinaHigh Magnetic Field Laboratory, Chinese Academy of SciencesHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of ChinaPolo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth.https://doi.org/10.1038/s41467-017-01647-5 |