Complex Formation with Monomeric α-Tubulin and Importin 13 Fosters c-Jun Protein Stability and Is Required for c-Jun’s Nuclear Translocation and Activity

Complex Formation with Monomeric α-Tubulin and Importin 13 Fosters c-Jun Protein Stability and Is Required for c-Jun’s Nuclear Translocation and Activity

Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers. They are essential for a number of cellular processes, including intracellular trafficking and mitosis. Tubulin-binding chemotherapeutics are used to treat different types of tumors, includi...

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Bibliographic Details
Main Authors: Melanie Kappelmann-Fenzl, Silke Kuphal, Rosemarie Krupar, Dirk Schadendorf, Viktor Umansky, Lily Vardimon, Claus Hellerbrand, Anja-Katrin Bosserhoff
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
ap1
c-jun
transcription factor
tubulin
importin
Online Access:https://www.mdpi.com/2072-6694/11/11/1806

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