Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer...
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MDPI AG
2015-09-01
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| Series: | Diagnostics |
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| Online Access: | http://www.mdpi.com/2075-4418/5/3/372 |
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doaj-f6dee9656953426aa1b6e4a371499e6b2020-11-24T23:37:55ZengMDPI AGDiagnostics2075-44182015-09-015337238210.3390/diagnostics5030372diagnostics5030372Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and MonitoringKamilla Westarp Zornhagen0Malene M. Clausen1Anders E. Hansen2Ian Law3Fintan J. McEvoy4Svend A. Engelholm5Andreas Kjær6Annemarie T. Kristensen7Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, DenmarkDepartment of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345E, DK-2800 Kgs. Lyngby, DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, DenmarkDepartment of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, DenmarkDepartment of Radiation Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2200 Copenhagen N, DenmarkDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, DenmarkDepartment of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, DenmarkGlycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.http://www.mdpi.com/2075-4418/5/3/37218F-FDG18F-FLT64Cu-ATSMpositron emission tomographyPET/CTindividualized response monitoringcanine fibrosarcoma |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kamilla Westarp Zornhagen Malene M. Clausen Anders E. Hansen Ian Law Fintan J. McEvoy Svend A. Engelholm Andreas Kjær Annemarie T. Kristensen |
| spellingShingle |
Kamilla Westarp Zornhagen Malene M. Clausen Anders E. Hansen Ian Law Fintan J. McEvoy Svend A. Engelholm Andreas Kjær Annemarie T. Kristensen Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring Diagnostics 18F-FDG 18F-FLT 64Cu-ATSM positron emission tomography PET/CT individualized response monitoring canine fibrosarcoma |
| author_facet |
Kamilla Westarp Zornhagen Malene M. Clausen Anders E. Hansen Ian Law Fintan J. McEvoy Svend A. Engelholm Andreas Kjær Annemarie T. Kristensen |
| author_sort |
Kamilla Westarp Zornhagen |
| title |
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring |
| title_short |
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring |
| title_full |
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring |
| title_fullStr |
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring |
| title_full_unstemmed |
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring |
| title_sort |
use of molecular imaging markers of glycolysis, hypoxia and proliferation (18f-fdg, 64cu-atsm and 18f-flt) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring |
| publisher |
MDPI AG |
| series |
Diagnostics |
| issn |
2075-4418 |
| publishDate |
2015-09-01 |
| description |
Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response. |
| topic |
18F-FDG 18F-FLT 64Cu-ATSM positron emission tomography PET/CT individualized response monitoring canine fibrosarcoma |
| url |
http://www.mdpi.com/2075-4418/5/3/372 |
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