Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats.

Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats.

Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) and may play a role in the development of cognitive impairment (CI). The present study evaluates the correlation of cognitive deficits with...

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Bibliographic Details
Main Authors: Sabrina Degaspari, Carmen Branco Tzanno-Martins, Clarice Kazue Fujihara, Roberto Zatz, João Paulo Branco-Martins, Tania Araujo Viel, Hudson de Souza Buck, Ana Maria Marques Orellana, Ana Elisa Böhmer, Larissa de Sá Lima, Diana Zukas Andreotti, Carolina Demarchi Munhoz, Cristoforo Scavone, Elisa Mitiko Kawamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125271

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