Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

Acute pancreatitis (AP) is characterized by early activation of intra-acinar proteases followed by acinar cell death and inflammation. Cellular oxidative stress is a key mechanism underlying these pathological events. Sulforaphane (SFN) is a natural organosulfur antioxidant with undescribed effects...

Full description

Bibliographic Details
Main Authors:	Zhaojun Dong, Haixiao Shang, Yong Q. Chen, Li-Long Pan, Madhav Bhatia, Jia Sun
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2016/7864150

Similar Items

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
by: Xuling Su, et al.
Published: (2018-01-01)

Protective Mechanism of Sulforaphane on Cadmium-Induced Sertoli Cell Injury in Mice Testis via Nrf2/ARE Signaling Pathway
by: Shu-Hua Yang, et al.
Published: (2018-07-01)

Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway.
by: Hong Pan, et al.
Published: (2014-01-01)

Suppression of pro-inflammatory signalling pathways by sulforaphane
by: Folkard, Danielle
Published: (2014)

Pancreatic Acinar Cell Carcinoma
by: Dominique Béchade, et al.
Published: (2016-05-01)

A case of pancreatic acinar cell carcinoma
by: LIU Feng, et al.
Published: (2018-03-01)

Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway
by: Lin H, et al.
Published: (2014-07-01)

Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway
by: Zhihong Zhao, et al.
Published: (2016-01-01)

Sulforaphane Treatment of Stress Urinary Incontinence Via the Nrf2-ARE Pathway in a Rat Model
by: Xiang Wan, et al.
Published: (2017-12-01)

Moxibustion Ameliorates Ovarian Reserve in Rats by Mediating Nrf2/HO-1/NLRP3 Anti-Inflammatory Pathway
by: Ge Lu, et al.
Published: (2021-01-01)

Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways
by: Yong Li, et al.
Published: (2018-01-01)

Effects of Baicalin on inflammatory mediators and pancreatic acinar cell apoptosis in rats with sever acute pancreatitis
by: zhang xiping, et al.
Published: (2009-02-01)

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission
by: Gary B. O'Mealey, et al.
Published: (2017-04-01)

Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2.
by: Andrea Kinga Marias Furuya, et al.
Published: (2016-04-01)

Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways
by: Shu-Hua Yang, et al.
Published: (2016-10-01)

Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice
by: Jiaji Hu, et al.
Published: (2021-01-01)

Nrf-2 activator sulforaphane protects retinal cells from oxidative stress-induced retinal injury
by: Hao-Yun Chang, et al.
Published: (2020-08-01)

The mechanism of exocytosis in the pancreatic acinar cell
by: Pickett, James Ashby
Published: (2007)

Corrigendum to “Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways”
by: Yong Li, et al.
Published: (2018-01-01)

Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling
by: Xin Chen, et al.
Published: (2018-10-01)

Sulforaphane Protect Against Cadmium-Induced Oxidative Damage in mouse Leydigs Cells by Activating Nrf2/ARE Signaling Pathway
by: Shu-Hua Yang, et al.
Published: (2019-02-01)

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
by: Yang Bai, et al.
Published: (2015-01-01)

Sulforaphane alleviates methamphetamine-induced oxidative damage and apoptosis via the Nrf2-mediated pathway in vitro and in vivo
by: Qi Xiong, et al.
Published: (2020-01-01)

Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells
by: Rahul Checker, et al.
Published: (2015-12-01)

Papillocystic Variant of Acinar Cell Pancreatic Carcinoma
by: Jasim Radhi, et al.
Published: (2010-01-01)

Polarised calcium signalling in pancreatic acinar cells
by: Ashby, Michael Charles
Published: (2002)

Calcium signalling in mouse pancreatic acinar cells
by: Rowles, Sarah-Jayne
Published: (1996)

An investigation of the mechanism of secretion in the pancreatic acinar cell
by: Hansen, N.
Published: (2000)

Studies on the role of Ca²⁺ in the pancreatic acinar cell
by: Ansah, Twum-Ampofo
Published: (2010)

Studies on the role of Ca²⁺ in the pancreatic acinar cell
by: Ansah, Twum-Ampofo
Published: (2010)

Stimulus - Secretion Coupling in the Pancreatic Acinar Cell
by: Smith, R. K.
Published: (1976)

Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium.
by: Vivek Mishra, et al.
Published: (2013-01-01)

CHRONIC ETHANOL CONSUMPTION INHIBITS MULTIPLE APOPTOTIC PATHWAYS IN THE RAT PANCREATIC ACINAR CELL
by: Fortunato, Franco
Published: (2003)

Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation
by: Wenpeng Cui, et al.
Published: (2012-01-01)

Sulforaphane ameliorates cadmium induced hepatotoxicity through the up-regulation of /Nrf2/ARE pathway and the inactivation of NF-κB
by: Qingfeng He, et al.
Published: (2021-02-01)

Sulforaphane Inhibits Osteoclastogenesis via Suppression of the Autophagic Pathway
by: Tingting Luo, et al.
Published: (2021-01-01)

Lipoxin A4 Ameliorates Acute Pancreatitis-Associated Acute Lung Injury through the Antioxidative and Anti-Inflammatory Effects of the Nrf2 Pathway
by: Wen Ye, et al.
Published: (2019-01-01)

The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines.
by: Su-Jin Moon, et al.
Published: (2021-01-01)

Amelioration of experimental acute pancreatitis with Dachengqi Decoction via regulation of necrosis-apoptosis switch in the pancreatic acinar cell.
by: Jia Wang, et al.
Published: (2012-01-01)

Stepwise differentiation of pancreatic acinar cells from mES cells by manipulating signalling pathway
by: Delaspre, Fabien
Published: (2011)

Cannot write session to /tmp/vufind_sessions/sess_k6ads0il800h7rq2b1nvgqf86f