Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection
Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18168-3 |
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doaj-f6c324bdfe0e47ba949b2bdd1df1f91a2021-08-29T11:39:19ZengNature Publishing GroupNature Communications2041-17232020-08-0111111210.1038/s41467-020-18168-3Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infectionPiero Giansanti0Jeroen R. P. M. Strating1Kyra A. Y. Defourny2Ieva Cesonyte3Alexia M. S. Bottino4Harm Post5Ekaterina G. Viktorova6Vien Quang Tri Ho7Martijn A. Langereis8George A. Belov9Esther N. M. Nolte-‘t Hoen10Albert J. R. Heck11Frank J. M. van Kuppeveld12Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityDepartment of Veterinary Medicine, University of Maryland and VA-MD College of Veterinary MedicineVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Veterinary Medicine, University of Maryland and VA-MD College of Veterinary MedicineDivision of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityVirology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityHere, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during virus infection.https://doi.org/10.1038/s41467-020-18168-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Piero Giansanti Jeroen R. P. M. Strating Kyra A. Y. Defourny Ieva Cesonyte Alexia M. S. Bottino Harm Post Ekaterina G. Viktorova Vien Quang Tri Ho Martijn A. Langereis George A. Belov Esther N. M. Nolte-‘t Hoen Albert J. R. Heck Frank J. M. van Kuppeveld |
| spellingShingle |
Piero Giansanti Jeroen R. P. M. Strating Kyra A. Y. Defourny Ieva Cesonyte Alexia M. S. Bottino Harm Post Ekaterina G. Viktorova Vien Quang Tri Ho Martijn A. Langereis George A. Belov Esther N. M. Nolte-‘t Hoen Albert J. R. Heck Frank J. M. van Kuppeveld Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection Nature Communications |
| author_facet |
Piero Giansanti Jeroen R. P. M. Strating Kyra A. Y. Defourny Ieva Cesonyte Alexia M. S. Bottino Harm Post Ekaterina G. Viktorova Vien Quang Tri Ho Martijn A. Langereis George A. Belov Esther N. M. Nolte-‘t Hoen Albert J. R. Heck Frank J. M. van Kuppeveld |
| author_sort |
Piero Giansanti |
| title |
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| title_short |
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| title_full |
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| title_fullStr |
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| title_full_unstemmed |
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| title_sort |
dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-08-01 |
| description |
Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during virus infection. |
| url |
https://doi.org/10.1038/s41467-020-18168-3 |
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