Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory

• Main Authors: Mahdieh Anoush, Ali Jani, Moosa Sahebgharani, Mohammad Reza Jafari
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2016-02-01
• Series: Iranian Journal of Psychiatry
• Subjects: Estradiol Valerate; Raloxifene; Step-Down; Sensitization; Memory; Opioids
• Online Access: https://ijps.tums.ac.ir/index.php/ijps/article/view/10
• ISSN: 1735-4587; 2008-2215

 Objective: In this study, the effects of estradiol valerate and raloxifenea selective estrogen receptor modulator; (SERM) on morphine induced sensitization were examined in mice memory, according to the step-down passive avoidance task. Method:The mice received morphine or estradiol and raloxifene for three days alone or in combination with morphine. After a drug free period of 5 days, the subjects received saline or morphine as pre- training treatments followed by a pre-test saline administration. The memory retrieval was evaluated using step-down passive avoidance test both on the training and test day. Results:The results illustrated that the three- day administration of morphine induced sensitization through the enhancement of memory retrieval (morphine induced sensitization in mice memory). Both the three- day administration of estradiol valerate alone and with morphine (5 mg/kg) restored memory. On the other hand, the three- day administration of raloxifene had no effect on memory retrieval alone, but declined morphine induced sensitization in mice memory. Conclusion:The results of the study indicated that there is an interaction between estrogen receptor modulators and morphine induced sensitization in mice memory.