Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradati...

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Bibliographic Details
Main Authors: Chi Zhang, Ziling Zeng, Dong Cui, Shasha He, Yuyan Jiang, Jingchao Li, Jiaguo Huang, Kanyi Pu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23194-w
Description
Summary:Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy.
ISSN:2041-1723

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