Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

Plants, algae and most bacteria synthesize 5-aminolevulinic acid (ALA), the universal precursor of tetrapyrroles such as heme, chlorophyll and coenzyme B12, by a two-step transformation involving the NADPH-dependent glutamyl-tRNA reductase (HemA), which reduces tRNA-bound glutamate to glutamate-1-se...

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Bibliographic Details
Main Authors: Caterina Nardella, Dalila Boi, Martino L. di Salvo, Anna Barile, Jörg Stetefeld, Angela Tramonti, Roberto Contestabile
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
Acinetobacter baumannii
pyridoxal 5′-phosphate-dependent enzymes
HemA
HemL
glutamyl-tRNA reductase
glutamate-1-semialdehyde aminomutase
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00006/full

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https://www.frontiersin.org/article/10.3389/fmolb.2019.00006/full

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