Bioscreening of Oxypeucedanin, a Known Furanocoumarin

• Main Authors: Seyed Mehdi Razavi, Saber Zahri, Zahra Motamed, Ghader Ghasemi
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: Allelopathy; Antiproliferative agent; Cytotoxic activity; Oxypeucedanin; Phytotoxic activity; Prangos uloptera
• Online Access: http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/summer/a10.pdf
• ISSN: 2008-3866; 2008-3874

Objective(s)As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. Oxypeucedanine also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at C-5 of the nucleus. To our knowledge, there are few reports on pharmacological and biological activities of this compound. In the present work, we focused on some bioactive aspects of it.Materials and MethodsIn the present work, the compound was purified from Prangos uloptera using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.Results Our results revealed that oxypeucedanin exhibit considerable phytotoxic activity and might play an allelopathic role for plants. The compound indicated high cytotoxic activity with IC50 value of 314 µg/ml. No antipathogenic and antioxidant activity were found for oxypeucedanin in this study. ConclusionWe conclude that oxypeucedanin (found in some vegetables) can be considered as an antiproliferative agent. Keywords: Allelopathy, Antiproliferative agent, Cytotoxic activity, Oxypeucedanin, Phytotoxic activity, Prangos uloptera