Microwave-Assisted Synthesis of Some Potential Bioactive Imidazolium-Based Room-Temperature Ionic Liquids

• Main Authors: Ahmed H. Albalawi, Wael S. El-Sayed, Ateyatallah Aljuhani, Saud M. Almutairi, Nadjet Rezki, Mohamed R. Aouad, Mouslim Messali
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Molecules
• Subjects: ionic liquids; imidazolium; green synthesis; microwave irradiation; toxicity; antibacterial activity
• Online Access: http://www.mdpi.com/1420-3049/23/7/1727
• ISSN: 1420-3049

An environmentally-friendly and easy synthesis of a series of novel functionalized imidazolium-based ionic liquids (ILs) is described under both the conventional procedure and microwave irradiation. The structures of newly synthesized room-temperature ionic liquids (RTILs) were established by different spectral analyses. All ILs (1–14) were screened for their in vitro antimicrobial activity against a panel of clinically isolated bacteria. The results of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) showed that some of the tested ILs are very promising anti-bacterial agents especially those containing an alkyl chain with a phenyl group (most notably 1, 2, 12, and 13).