M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident mesenchymal stem cells (LR-MSCs) have been identified as an important...

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Bibliographic Details
Main Authors: Jiwei Hou, Jingyan Shi, Ling Chen, Zhongyang Lv, Xiang Chen, Honghui Cao, Zou Xiang, Xiaodong Han
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Idiopathic pulmonary fibrosis (IPF)
M2 macrophages
Lung resident mesenchymal stem cells (LR-MSCs)
Myofibroblast differentiation
Online Access:http://link.springer.com/article/10.1186/s12964-018-0300-8

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