Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

Factors affecting the developing neonatal gut microbiome and immune networks may increase the risk of developing complex immune disorders such as inflammatory bowel diseases (IBD). In particular, peripartum antibiotics have been suggested as risk factors for human IBD, although direct evidence is la...

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Bibliographic Details
Main Authors: Jun Miyoshi, Alexandria M. Bobe, Sawako Miyoshi, Yong Huang, Nathaniel Hubert, Tom O. Delmont, A. Murat Eren, Vanessa Leone, Eugene B. Chang
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
microbiome
host-microbe interactions
microbiome intervention
immune development
microbial assemblage
dysbiosis
inflammatory bowel diseases
complex immune disorders
vertical transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308914

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