Liposomal Elongation Factor-1α Triggers Effector CD4 and CD8 T Cells for Induction of Long-Lasting Protective Immunity against Visceral Leishmaniasis

Liposomal Elongation Factor-1α Triggers Effector CD4 and CD8 T Cells for Induction of Long-Lasting Protective Immunity against Visceral Leishmaniasis

Despite advances, identification and formulation of safe and effective vaccine for long-lasting protection against leishmaniasis is still inadequate. In this study, we have identified a novel antigen, leishmanial elongation factor-1α (EF1-α), as an immunodominant component of solubilized leishmanial...

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Bibliographic Details
Main Authors: Abdus Sabur, Sudipta Bhowmick, Rudra Chhajer, Sarfaraz Ahmad Ejazi, Nicky Didwania, Mohammad Asad, Anirban Bhattacharyya, Utsa Sinha, Nahid Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis
cationic liposome
vaccine
elongation factor-1α
Th1/Th2 response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00018/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00018/full

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