CHANGES OF THE LACTOFERRIN CONTENT IN PATIENTS WITH CHRONIC TRAUMATIC INJURIE OF THE ORAL MUCOSA BEFORE AND AFTER THE THERAPY

• Main Authors: M.A. Goray, L.O. Kovalchuk
• Format: Article
• Language: English
• Published: Ukrainian Medical Stomatological Academy 2015-03-01
• Series: Український стоматологічний альманах
• Subjects: lactoferrin, chronic traumatic injuries, oral mucosa.
• Online Access: https://dental-almanac.org/index.php/journal/article/view/4

The article presents the laboratory examination results of 110 patients with chronic traumatic injuries of the oral mucosa. Changes of the lactoferrin content in the patients' oral fluid were determined before and after the therapy. The highest lactoferrin content was revealed in the oral fluid of apparently healthy donors. On the contrary, in all groups of the patients a significant (p<0,001) reduction of that index could be observed. After the provided combination therapy a significant increase of the index could be observed in the main group of patients that proved high efficacy of the proposed treatment method for patients with chronic mechanical traumatic injuries of the oral mucosa. Introduction. The article presents the laboratory examination results of 110 patients with chronic traumatic injuries of the oral mucosa. Protection of the oral mucosa from local injuring factors first of all is connected with the condition of the local immune system. Taking into account involvement of the lactoferrin protein in regulation of the oral nonspecific immunity system the estimation of its content in the patients' oral fluid and determination of changes in its concentration during the combination therapy is important. Research objective: to study the lactoferrin content in the oral fluid of patients with chronic mechanical injuries of the oral mucosa and the nature of changes in its concentration during the provided combination therapy. Materials and methods. A comprehensive immunological examination of the oral fluid in the patients with chronic traumatic injuries, aged from 50 to 78 years, in 30 healthy persons without mucosa injuries and in 110 patients of the same age category was carried out. Among the latter 35 persons had traumatic erythema, 13 – decubital ulcers, 19 – chronic traumatic erosion, 37 – flat leukoplakia and 6 – verrucous leukoplakia of the oral mucosa. The quantitative content of lactoferrin in the oral fluid was determined using the reagents LACTOFERRIN- IFA-BEST and the method of the solid-phase immune-enzyme analysis. The lactoferrin content in the oral fluid was measured before the therapy and 1 month after the curative measures. Results and discussion. Changes of the lactoferrin content in the patients' oral fluid were determined before and after the therapy. The highest lactoferrin content was revealed in the oral fluid of apparently healthy donors. On the contrary, in all groups of the patients a significant (p<0,001) reduction of that index could be observed. After the provided combination therapy a significant increase of the index could be observed in the main group of patients that proved high efficacy of the proposed treatment method for patients with chronic mechanical traumatic injuries of the oral mucosa. Conclusion. 1. The revealed significant reduction of lactoferrin concentration in the oral fluid under inflammatory-destructive processes can be considered as a specific marker of a chronic mechanical injury of the oral mucosa. 2. Major abnormalities of the main components of the oral immune system, suppression of the non-specific protection affect the course of chronic mechanical injuries of the oral mucosa and require corresponding correction. 3. The study results prove high efficacy of the proposed treatment method for patients with chronic mechanical injuries of the oral mucosa. The prospect of the further research is to develop and use lactoferrin-based drugs for local treatment of chronic mechanical injuries of the oral mucosa.