Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular mechanisms underlying drug export and inhibition of t...

Full description

Bibliographic Details
Main Authors: Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19397-2

Internet

https://doi.org/10.1038/s41467-020-19397-2

Similar Items