Malfunctioning of the iron-sulfur cluster assembly machinery in Saccharomyces cerevisiae produces oxidative stress via an iron-dependent mechanism, causing dysfunction in respiratory complexes.

Malfunctioning of the iron-sulfur cluster assembly machinery in Saccharomyces cerevisiae produces oxidative stress via an iron-dependent mechanism, causing dysfunction in respiratory complexes.

Biogenesis and recycling of iron-sulfur (Fe-S) clusters play important roles in the iron homeostasis mechanisms involved in mitochondrial function. In Saccharomyces cerevisiae, the Fe-S clusters are assembled into apoproteins by the iron-sulfur cluster machinery (ISC). The aim of the present study w...

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Bibliographic Details
Main Authors: Mauricio Gomez, Rocío V Pérez-Gallardo, Luis A Sánchez, Alma L Díaz-Pérez, Christian Cortés-Rojo, Victor Meza Carmen, Alfredo Saavedra-Molina, Javier Lara-Romero, Sergio Jiménez-Sandoval, Francisco Rodríguez, José S Rodríguez-Zavala, Jesús Campos-García
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4214746?pdf=render

Internet

http://europepmc.org/articles/PMC4214746?pdf=render

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