Neuropsychological Outcome One Year after Carotid Revascularization: A before-and-after Study

• Main Authors: Laura Casas-Hernanz, Maite Garolera, Dolors Badenes, Salvador Quintana, Susana Mill?n, Noemi Calzado, Jorge de Francisco, Josep Royo, Miquel Aguilar
• Format: Article
• Language: English
• Published: Medrang 2017-12-01
• Series: Vascular Specialist International
• Subjects: Endarterectomy; Carotid stenosis; Angioplasty; Cognition; Neuropsychological tests
• Online Access: http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2017.33.4.146

Purpose: The aim of our study was to determine the clinical profile of patients considered cognitive ‘responders’ to surgery in order to establish clinical variables associated with a favorable cognitive performance. Materials and Methods: A total of 70 patients were included in the study. A well-validated, comprehensive standardized neurocognitive battery of tests of about 2 hours was administered. Patients were examined twice, 1-week before surgery and 1-year postoperatively. The criterion to be included in the ‘responder’ group was the following: to obtain a positive difference between post-revascularization and pre-revascularization neuropsychological assessment ≥1 standard deviation in ≥2 tests. Results: Twenty-seven patients (38.6%) were cognitive responders to treatment. In bivariate analysis between responders and non-responders, presence of atrophy (P=0.003), small vessels (P=0.577), symptoms (P=0.046), and age (P=0.030) were the factors statistically significant. When comparing cognitive performance before and after carotid revascularization, significant differences were observed in semantic fluency with a lower performance after 12 months (P=0.004, d=0.29), and in the Language index (Repeatable Battery for the Assessment of Neuropsychological Status) (P=0.005, d=0.34). Conclusion: Patients without neurological symptoms, of a younger age and without atrophy and white matter small vessel lesions are better cognitive responders 1-year after carotid revascularization.