DNA-Platinum Thin Films for Use in Chemoradiation Therapy Studies

Dry films of platinum chemotherapeutic drugs covalently bound to plasmid DNA (Pt-DNA) represent a useful experimental model to investigate direct effects of radiation on DNA in close proximity to platinum chemotherapeutic agents, a situation of considerable relevance to understand the mechanisms und...

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Bibliographic Details
Main Authors: Mohammad Rezaee, Elahe Alizadeh, Darel Hunting, Léon Sanche
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2012/923914