The role of hereditary colorectal cancer registries in identification of high risk patients and treatment improvement

• Main Authors: D. Yu. Pikunov, M. Kh. Toboeva, A. S. Tsukanov
• Format: Article
• Language: Russian
• Published: MONIKI 2018-04-01
• Series: Alʹmanah Kliničeskoj Mediciny
• Subjects: colorectal cancer; epidemiology; patient registry; screening; familial adenomatous polyposis; lynch syndrome; incidence; mortality
• Online Access: https://www.almclinmed.ru/jour/article/view/752

Up to 10% of cases of sporadic colorectal cancer are considered to be related to hereditary genetic factors. The rates of colorectal cancer related to already identified genetic factors is about 5%. In the last decades, due to the development of comprehensive familial cancer registries and progress in genomics, clinical diagnostic criteria for specific hereditary syndromes have been proposed and multiple genes have been detected whose germ mutations increase the risk of neoplastic syndromes. Identification of individual patients and families with hereditary syndromes (familial adenomatous polyposis, Lynch syndrome, MYH-associated polyposis, hamartoma syndromes) may help to develop an effective strategy for monitoring and, as the results, for reduction of cancer incidence and improvement of survival. The aim of this literature review is to assess the influence of the registries of patients with hereditary types of colorectal cancer on its incidence and long-term treatment results.