The DNA damage response in immunotherapy and radiation

Purpose: Deficiencies in DNA damage repair (DDR) and response represent a common alteration in tumors, and exploitation of this feature using therapeutics has become more prominent. Methods and materials: Recent work has highlighted the important interaction between DDR defects, as well as DDR targe...

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Bibliographic Details
Main Authors: Robert M. Samstein, MD, PhD, Nadeem Riaz, MD
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109418301490