Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model

Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model

Human Metapneumovirus (hMPV) is a leading respiratory viral pathogen associated with bronchiolitis, pneumonia, and asthma exacerbation in young children, the elderly and immunocompromised individuals. The development of a potential vaccine against hMPV requires detailed understanding of the host imm...

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Main Authors: Nagarjuna R. Cheemarla, Antonieta Guerrero-Plata
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Pathogens
Subjects:
human metapneumovirus
paramyxovirus
mouse model
immune responses
Online Access:http://www.mdpi.com/2076-0817/4/3/682
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spelling doaj-f6552bb77aab4a8ca87146dcc2bb71f02020-11-24T22:26:29ZengMDPI AGPathogens2076-08172015-09-014368269610.3390/pathogens4030682pathogens4030682Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse ModelNagarjuna R. Cheemarla0Antonieta Guerrero-Plata1Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USADepartment of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USAHuman Metapneumovirus (hMPV) is a leading respiratory viral pathogen associated with bronchiolitis, pneumonia, and asthma exacerbation in young children, the elderly and immunocompromised individuals. The development of a potential vaccine against hMPV requires detailed understanding of the host immune system, which plays a significant role in hMPV pathogenesis, susceptibility and vaccine efficacy. As a result, animal models have been developed to better understand the mechanisms by which hMPV causes disease. Several animal models have been evaluated and established so far to study the host immune responses and pathophysiology of hMPV infection. However, inbred laboratory mouse strains have been one of the most used animal species for experimental modeling and therefore used for the studies of immunity and immunopathogenesis to hMPV. This review summarizes the contributions of the mouse model to our understanding of the immune response against hMPV infection.http://www.mdpi.com/2076-0817/4/3/682human metapneumovirusparamyxovirusmouse modelimmune responses
collection DOAJ
language English
format Article
sources DOAJ
author Nagarjuna R. Cheemarla
Antonieta Guerrero-Plata
spellingShingle Nagarjuna R. Cheemarla
Antonieta Guerrero-Plata
Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
Pathogens
human metapneumovirus
paramyxovirus
mouse model
immune responses
author_facet Nagarjuna R. Cheemarla
Antonieta Guerrero-Plata
author_sort Nagarjuna R. Cheemarla
title Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
title_short Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
title_full Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
title_fullStr Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
title_full_unstemmed Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model
title_sort immune response to human metapneumovirus infection: what we have learned from the mouse model
publisher MDPI AG
series Pathogens
issn 2076-0817
publishDate 2015-09-01
description Human Metapneumovirus (hMPV) is a leading respiratory viral pathogen associated with bronchiolitis, pneumonia, and asthma exacerbation in young children, the elderly and immunocompromised individuals. The development of a potential vaccine against hMPV requires detailed understanding of the host immune system, which plays a significant role in hMPV pathogenesis, susceptibility and vaccine efficacy. As a result, animal models have been developed to better understand the mechanisms by which hMPV causes disease. Several animal models have been evaluated and established so far to study the host immune responses and pathophysiology of hMPV infection. However, inbred laboratory mouse strains have been one of the most used animal species for experimental modeling and therefore used for the studies of immunity and immunopathogenesis to hMPV. This review summarizes the contributions of the mouse model to our understanding of the immune response against hMPV infection.
topic human metapneumovirus
paramyxovirus
mouse model
immune responses
url http://www.mdpi.com/2076-0817/4/3/682
work_keys_str_mv AT nagarjunarcheemarla immuneresponsetohumanmetapneumovirusinfectionwhatwehavelearnedfromthemousemodel
AT antonietaguerreroplata immuneresponsetohumanmetapneumovirusinfectionwhatwehavelearnedfromthemousemodel
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