Conditioned medium from M2b macrophages modulates the proliferation, migration, and apoptosis of pulmonary artery smooth muscle cells by deregulating the PI3K/Akt/FoxO3a pathway

Conditioned medium from M2b macrophages modulates the proliferation, migration, and apoptosis of pulmonary artery smooth muscle cells by deregulating the PI3K/Akt/FoxO3a pathway

Background Immunity and inflammation are considered to be central features of pulmonary artery hypertension (PAH), in which macrophages are one of the main components of inflammatory cell infiltration around the pulmonary artery. M2b macrophages, which are different from M1 and M2 macrophages, are b...

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Bibliographic Details
Main Authors: Suiqing Huang, Yuan Yue, Kangni Feng, Xiaolin Huang, Huayang Li, Jian Hou, Song Yang, Shaojie Huang, Mengya Liang, Guangxian Chen, Zhongkai Wu
Format: Article
Language:English
Published: PeerJ Inc. 2020-05-01
Series:PeerJ
Subjects:
M2b macrophages
Pulmonary artery hypertension
Macrophage
Pulmonary artery smooth muscle cells
Proliferation
Migration
Online Access:https://peerj.com/articles/9110.pdf

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