IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury

This study was undertaken to test two therapies for acute kidney injury (AKI) prevention, IGF-1, which is renal protective, and BTP-2, which is a calcium entry (SOCE) inhibitor. We utilized lipopolysaccharide (LPS) IP, as a systemic model of AKI and studied in five groups of animals. Three experimen...

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Bibliographic Details
Main Authors:	Samiksha Wasnik, Xiaolei Tang, Hongzheng Bi, Amir Abdipour, Edmundo E. Carreon, Brian Sutjiadi, Justin Lyu, Jintao Zhang, Sean Wilson, David J. Baylink
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	International Journal of Molecular Sciences
Subjects:	kidney injury vascular integrity LPS inflammation calcium signaling
Online Access:	https://www.mdpi.com/1422-0067/21/11/4095

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