A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase
Cosmetic practices that use skin-lightening agents to obtain desired skin tones or treat pigment abnormalities have been popular worldwide. However, the molecular and cellular mechanisms of these agents are still largely unknown. Here we identified a family of compounds, with the lead compound named...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-07-01
|
| Series: | Cosmetics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-9284/5/3/45 |
| id |
doaj-f637549954fc4871ab81a2b9d6629f9c |
|---|---|
| record_format |
Article |
| spelling |
doaj-f637549954fc4871ab81a2b9d6629f9c2020-11-25T02:35:45ZengMDPI AGCosmetics2079-92842018-07-01534510.3390/cosmetics5030045cosmetics5030045A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting TyrosinaseKristy Martinson0Noah Stueven1Aaron Monte2Cheng-chen Huang3Biology Department, University of Wisconsin-River Falls, River Falls, WI 54022, USABiology Department, University of Wisconsin-River Falls, River Falls, WI 54022, USADepartment of Chemistry and Biochemistry, University of Wisconsin-La Crosse, La Crosse, WI 54601, USABiology Department, University of Wisconsin-River Falls, River Falls, WI 54022, USACosmetic practices that use skin-lightening agents to obtain desired skin tones or treat pigment abnormalities have been popular worldwide. However, the molecular and cellular mechanisms of these agents are still largely unknown. Here we identified a family of compounds, with the lead compound named A11, that exhibited strong pigment reduction in developing zebrafish embryos. The pigment inhibition lasted for several days and is effective both before and after melanogenesis. By comparison with several known skin-lightening compounds, A11 appeared to be more potent and caused slower pigment recovery after withdrawal. A11, however, did not inhibit tyrosinase or cause apoptosis in melanocytes. We further found that A11 suppressed proliferation in melanocytes and reduced the number of differentiated melanocytes by activating MAPK (mitogen-activated protein kinase) and Akt. Finally, A11 also caused melanin reduction in mammalian melanocytes. Together, A11 might be a potent skin-lightening agent with novel mechanisms.http://www.mdpi.com/2079-9284/5/3/45skin-lighteningzebrafishtyrosinasemelanocyteproliferationdifferentiation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kristy Martinson Noah Stueven Aaron Monte Cheng-chen Huang |
| spellingShingle |
Kristy Martinson Noah Stueven Aaron Monte Cheng-chen Huang A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase Cosmetics skin-lightening zebrafish tyrosinase melanocyte proliferation differentiation |
| author_facet |
Kristy Martinson Noah Stueven Aaron Monte Cheng-chen Huang |
| author_sort |
Kristy Martinson |
| title |
A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase |
| title_short |
A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase |
| title_full |
A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase |
| title_fullStr |
A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase |
| title_full_unstemmed |
A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase |
| title_sort |
novel stilbene-like compound that reduces melanin through inhibiting melanocyte differentiation and proliferation without inhibiting tyrosinase |
| publisher |
MDPI AG |
| series |
Cosmetics |
| issn |
2079-9284 |
| publishDate |
2018-07-01 |
| description |
Cosmetic practices that use skin-lightening agents to obtain desired skin tones or treat pigment abnormalities have been popular worldwide. However, the molecular and cellular mechanisms of these agents are still largely unknown. Here we identified a family of compounds, with the lead compound named A11, that exhibited strong pigment reduction in developing zebrafish embryos. The pigment inhibition lasted for several days and is effective both before and after melanogenesis. By comparison with several known skin-lightening compounds, A11 appeared to be more potent and caused slower pigment recovery after withdrawal. A11, however, did not inhibit tyrosinase or cause apoptosis in melanocytes. We further found that A11 suppressed proliferation in melanocytes and reduced the number of differentiated melanocytes by activating MAPK (mitogen-activated protein kinase) and Akt. Finally, A11 also caused melanin reduction in mammalian melanocytes. Together, A11 might be a potent skin-lightening agent with novel mechanisms. |
| topic |
skin-lightening zebrafish tyrosinase melanocyte proliferation differentiation |
| url |
http://www.mdpi.com/2079-9284/5/3/45 |
| work_keys_str_mv |
AT kristymartinson anovelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT noahstueven anovelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT aaronmonte anovelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT chengchenhuang anovelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT kristymartinson novelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT noahstueven novelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT aaronmonte novelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase AT chengchenhuang novelstilbenelikecompoundthatreducesmelaninthroughinhibitingmelanocytedifferentiationandproliferationwithoutinhibitingtyrosinase |
| _version_ |
1724803540820426752 |