Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.

Mitotic repression of rRNA synthesis requires inactivation of the RNA polymerase I (Pol I)-specific transcription factor SL1 by Cdk1/cyclin B-dependent phosphorylation of TAF(I)110 (TBP-associated factor 110) at a single threonine residue (T852). Upon exit from mitosis, T852 is dephosphorylated by C...

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Bibliographic Details
Main Authors: Renate Voit, Jeanette Seiler, Ingrid Grummt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4449194?pdf=render

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