Current evidence for a role of the Kynurenine pathway of tryptophan metabolism in Multiple Sclerosis

Current evidence for a role of the Kynurenine pathway of tryptophan metabolism in Multiple Sclerosis

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The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules such as interferon-γ (IFN-γ) is the trigger for induction of the KP, driving a complex cascade of production of both neuroprotective and neurotoxic metabolit...

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Bibliographic Details
Main Authors: Michael D. Lovelace, Bianca Varney, Gayathri Sundaram, Nunzio Franco, Mei Li Ng, Saparna Pai, Chai K. Lim, Bruce J. Brew
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Immunology
Subjects:
Kynurenic Acid
Multiple Sclerosis
Quinolinic Acid
neurodegenerative disease
Neuroinflammation
multiphoton microscopy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00246/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00246/full

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