Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure....

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Main Authors:	Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09514-1

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spelling	doaj-f62feb23d732418d85b428408797a4db2021-05-11T11:29:41ZengNature Publishing GroupNature Communications2041-17232019-04-0110111410.1038/s41467-019-09514-1Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissueCaroline Araiz0Anqi Yan1Lucia Bettedi2Isabella Samuelson3Sam Virtue4Anne K. McGavigan5Christian Dani6Antonio Vidal-Puig7Lazaros C. Foukas8Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College LondonInstitute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College LondonInstitute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College LondonInstitute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College LondonUniversity of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s HospitalUniversity of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s HospitalUniversité Côte d’Azur, CNRS, Inserm, iBV, Faculté de MédecineUniversity of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s HospitalInstitute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College LondonInsulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.https://doi.org/10.1038/s41467-019-09514-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas
spellingShingle	Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue Nature Communications
author_facet	Caroline Araiz Anqi Yan Lucia Bettedi Isabella Samuelson Sam Virtue Anne K. McGavigan Christian Dani Antonio Vidal-Puig Lazaros C. Foukas
author_sort	Caroline Araiz
title	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_short	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_full	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_fullStr	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_full_unstemmed	Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
title_sort	enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of pi3k p110α inactivation in adipose tissue
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	Insulin/IGF-1 signalling plays an important role in the regulation of metabolism and ageing. Here the authors show that inactivation of the pathway component PI3K p110α in the adipose tissue of mice produces a beneficial metabolic effect by enhancing β-adrenergic signalling thus energy expenditure.
url	https://doi.org/10.1038/s41467-019-09514-1
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Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

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