Clinical study on doxofylline combined with inhalant treatment of acute attack of bronchial asthma

• Main Author: Ling Fan
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-05-01
• Series: Journal of Hainan Medical University
• Subjects: Bronchial asthma; Doxofylline; Inflammatory response; Immune response
• Online Access: http://www.hnykdxxb.com/PDF/201805/02.pdf

Objective: To study the effect of doxofylline combined with inhalant on inflammation and immune response in acute attack of bronchial asthma. Methods: Patients with acute attack of bronchial asthma who were treated in Ganquan People’s Hospital in Yan’an Shaanxi Province between May 2015 and October 2017 were chosen as the research subjects and randomly divided into the observation group who received doxofylline combined with inhalant treatment and the control group who received conventional inhalant treatment. The contents of inflammatory mediators and protease molecules in serum as well as the contents of immune cells in peripheral blood were measured before treatment and 3 d after treatment. Results: 3 d after treatment, Eotaxin, YKL40, LTB4, TGF-β1, POSTN, ADAM8, ADAM33 and MMP9 contents in serum as well as Th2, Th9 and Th17 contents in peripheral blood of both groups of patients were lower than those before treatment whereas TIMP1 contents in serum as well as Th1 and Treg contents in peripheral blood were higher than those before treatment, and Eotaxin, YKL40, LTB4, TGF-β1, POSTN, ADAM8, ADAM33 and MMP9 contents in serum as well as Th2, Th9 and Th17 contents in peripheral blood of observation group of patients were lower than those of control group whereas TIMP1 content in serum as well as Th1 and Treg contents in peripheral blood was higher than those of control group. Conclusion: Doxofylline combined with inhalant treatment of acute attack of bronchial asthma can more effectively inhibit the activation of inflammatory response and improve the immune response mediated by Th cells.