Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells

Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells

Background: Previous studies showed that suppression of pyruvate carboxylase (PC) expression in highly invasive breast cancer cell line, MDA-MB-231 inhibits cell growth as a consequence of the impaired cellular biosynthesis. However, the precise cellular mechanism underlying this growth restriction...

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Bibliographic Details
Main Authors: Khanti Rattanapornsompong, Janya Khattiya, Phatchariya Phannasil, Narumon Phaonakrop, Sittiruk Roytrakul, Sarawut Jitrapakdee, Chareeporn Akekawatchai
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Pyruvate carboxylase
Breast cancer
Metabolism
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820302132

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