High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study

Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was perfor...

Full description

Bibliographic Details
Main Authors: Corina-Alina Ispasoiu, Radu Chicea, Florin Vasile Stamatian, Florin Ispasoiu
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2013/576926
id doaj-f618b5d252844a19bdede3a9597bd386
record_format Article
spelling doaj-f618b5d252844a19bdede3a9597bd3862020-11-24T21:36:33ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/576926576926High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control StudyCorina-Alina Ispasoiu0Radu Chicea1Florin Vasile Stamatian2Florin Ispasoiu3Astra Clinic, Gr. Alexandrescu Street, No. 1, 550371 Sibiu, RomaniaObstetrics and Gynaecology Department, University of Medicine “Victor Papilian”, L. Blaga Street, No. 2-4, 550169 Sibiu, Romania1st Obstetrics and Gynaecology Department, University of Medicine and Pharmacy, “Iuliu Hatieganu”, Clinicilor Street, No. 1-3, 400006 Cluj-Napoca, RomaniaPolisano Clinic, Constitutiei Street, No. 24, 550253 Sibiu, RomaniaObjective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred eighteen women divided into case group (with at least two pregnancy losses, earlier than 20 weeks of gestation, and negative for the recurrent pregnancy loss testing) and control group (with at least one live birth, no pregnancy loss). FG (fasting glucose) and FI (fasting insulin) were determined for all patients. IR was evaluated by HOMA-IR index. Results. There were not significant differences between the mean age and BMI in cases and controls (). Fasting glucose was significantly higher in the control group (85.6 versus 79.8 ), but fasting insulin (15.24 versus 12.83, ) and HOMA-IR (2.98 versus 2.69, ) were significantly higher in the case group. Conclusion. In women with idiopathic recurrent pregnancy loss FI and IR are higher than those in women without spontaneous abortion.http://dx.doi.org/10.1155/2013/576926
collection DOAJ
language English
format Article
sources DOAJ
author Corina-Alina Ispasoiu
Radu Chicea
Florin Vasile Stamatian
Florin Ispasoiu
spellingShingle Corina-Alina Ispasoiu
Radu Chicea
Florin Vasile Stamatian
Florin Ispasoiu
High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
International Journal of Endocrinology
author_facet Corina-Alina Ispasoiu
Radu Chicea
Florin Vasile Stamatian
Florin Ispasoiu
author_sort Corina-Alina Ispasoiu
title High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
title_short High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
title_full High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
title_fullStr High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
title_full_unstemmed High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study
title_sort high fasting insulin levels and insulin resistance may be linked to idiopathic recurrent pregnancy loss: a case-control study
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2013-01-01
description Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss. Material and Method. A single center, case control study was performed on one hundred eighteen women divided into case group (with at least two pregnancy losses, earlier than 20 weeks of gestation, and negative for the recurrent pregnancy loss testing) and control group (with at least one live birth, no pregnancy loss). FG (fasting glucose) and FI (fasting insulin) were determined for all patients. IR was evaluated by HOMA-IR index. Results. There were not significant differences between the mean age and BMI in cases and controls (). Fasting glucose was significantly higher in the control group (85.6 versus 79.8 ), but fasting insulin (15.24 versus 12.83, ) and HOMA-IR (2.98 versus 2.69, ) were significantly higher in the case group. Conclusion. In women with idiopathic recurrent pregnancy loss FI and IR are higher than those in women without spontaneous abortion.
url http://dx.doi.org/10.1155/2013/576926
work_keys_str_mv AT corinaalinaispasoiu highfastinginsulinlevelsandinsulinresistancemaybelinkedtoidiopathicrecurrentpregnancylossacasecontrolstudy
AT raduchicea highfastinginsulinlevelsandinsulinresistancemaybelinkedtoidiopathicrecurrentpregnancylossacasecontrolstudy
AT florinvasilestamatian highfastinginsulinlevelsandinsulinresistancemaybelinkedtoidiopathicrecurrentpregnancylossacasecontrolstudy
AT florinispasoiu highfastinginsulinlevelsandinsulinresistancemaybelinkedtoidiopathicrecurrentpregnancylossacasecontrolstudy
_version_ 1725940771655254016