Molecular basis for protein–protein interactions

• Main Authors: Brandon Charles Seychell, Tobias Beck
• Format: Article
• Language: English
• Published: Beilstein-Institut 2021-01-01
• Series: Beilstein Journal of Organic Chemistry
• Subjects: characterisation methods; heterooligomeric complex; homooligomeric complex; molecular interactions; protein–protein interactions
• Online Access: https://doi.org/10.3762/bjoc.17.1
• ISSN: 1860-5397

This minireview provides an overview on the current knowledge of protein–protein interactions, common characterisation methods to characterise them, and their role in protein complex formation with some examples. A deep understanding of protein–protein interactions and their molecular interactions is important for a number of applications, including drug design. Protein–protein interactions and their discovery are thus an interesting avenue for understanding how protein complexes, which make up the majority of proteins, work.