Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
Abstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided i...
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doaj-f614db309f344c22aa5625c9c7b52ef32021-08-22T11:18:50ZengBMCGut Pathogens1757-47492021-08-011311810.1186/s13099-021-00450-4Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritisPai-Jui Yeh0Cheng-Tang Chiu1Ming-Wei Lai2Ren-Chin Wu3Chien-Ming Chen4Chia-Jung Kuo5Jun-Te Hsu6Ming-Yao Su7Wei-Pin Lin8Tsung-Hsing Chen9Puo-Hsien Le10Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Pathology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Medical Imaging and Interventions, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of General Surgery, Chang Gung Memorial Hospital, Linkou BranchTaiwan Association of the Study of Small Intestinal DiseaseDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchAbstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided into CMV and non-CMV groups according to immunohistochemistry staining results. The risk factors, clinical presentations, endoscopic features, treatments, outcomes, and prognostic factors of CMV enteritis were then analyzed. Results Forty-two patients (18 CMV, 24 non-CMV group) were included in the study. Major clinical presentations in the CMV group included gastrointestinal bleeding (72.2%), abdominal pain (55.6%), and fever (33.3%); ulcers (72.2%) were the most common endoscopic findings. In-hospital and overall mortality rates were 27.8% and 38.9%, respectively; and longer hospital stays and higher overall mortality rates were observed. Radiotherapy and C-reactive protein levels were prognostic factors for in-hospital mortality. The risk factors for CMV enteritis included immunocompromised status (p = 0.013), steroid use (p = 0.014), shock (p = 0.031), concurrent pneumonia (p = 0.01), antibiotic exposure (p < 0.001), radiotherapy (p = 0.027), chronic kidney disease (p = 0.041), and CMV colitis (p = 0.031). Conclusions Physicians should pay attention to the characteristics of CMV enteritis in high-risk patients to make an early diagnosis and potentially improve the clinical outcome.https://doi.org/10.1186/s13099-021-00450-4Cytomegalovirus enteritisEndoscopyRisk factorPrognostic factorImmunohistochemistry staining |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pai-Jui Yeh Cheng-Tang Chiu Ming-Wei Lai Ren-Chin Wu Chien-Ming Chen Chia-Jung Kuo Jun-Te Hsu Ming-Yao Su Wei-Pin Lin Tsung-Hsing Chen Puo-Hsien Le |
spellingShingle |
Pai-Jui Yeh Cheng-Tang Chiu Ming-Wei Lai Ren-Chin Wu Chien-Ming Chen Chia-Jung Kuo Jun-Te Hsu Ming-Yao Su Wei-Pin Lin Tsung-Hsing Chen Puo-Hsien Le Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis Gut Pathogens Cytomegalovirus enteritis Endoscopy Risk factor Prognostic factor Immunohistochemistry staining |
author_facet |
Pai-Jui Yeh Cheng-Tang Chiu Ming-Wei Lai Ren-Chin Wu Chien-Ming Chen Chia-Jung Kuo Jun-Te Hsu Ming-Yao Su Wei-Pin Lin Tsung-Hsing Chen Puo-Hsien Le |
author_sort |
Pai-Jui Yeh |
title |
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
title_short |
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
title_full |
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
title_fullStr |
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
title_full_unstemmed |
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
title_sort |
clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis |
publisher |
BMC |
series |
Gut Pathogens |
issn |
1757-4749 |
publishDate |
2021-08-01 |
description |
Abstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided into CMV and non-CMV groups according to immunohistochemistry staining results. The risk factors, clinical presentations, endoscopic features, treatments, outcomes, and prognostic factors of CMV enteritis were then analyzed. Results Forty-two patients (18 CMV, 24 non-CMV group) were included in the study. Major clinical presentations in the CMV group included gastrointestinal bleeding (72.2%), abdominal pain (55.6%), and fever (33.3%); ulcers (72.2%) were the most common endoscopic findings. In-hospital and overall mortality rates were 27.8% and 38.9%, respectively; and longer hospital stays and higher overall mortality rates were observed. Radiotherapy and C-reactive protein levels were prognostic factors for in-hospital mortality. The risk factors for CMV enteritis included immunocompromised status (p = 0.013), steroid use (p = 0.014), shock (p = 0.031), concurrent pneumonia (p = 0.01), antibiotic exposure (p < 0.001), radiotherapy (p = 0.027), chronic kidney disease (p = 0.041), and CMV colitis (p = 0.031). Conclusions Physicians should pay attention to the characteristics of CMV enteritis in high-risk patients to make an early diagnosis and potentially improve the clinical outcome. |
topic |
Cytomegalovirus enteritis Endoscopy Risk factor Prognostic factor Immunohistochemistry staining |
url |
https://doi.org/10.1186/s13099-021-00450-4 |
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