Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis

Abstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided i...

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Main Authors: Pai-Jui Yeh, Cheng-Tang Chiu, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Chia-Jung Kuo, Jun-Te Hsu, Ming-Yao Su, Wei-Pin Lin, Tsung-Hsing Chen, Puo-Hsien Le
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Gut Pathogens
Subjects:
Online Access:https://doi.org/10.1186/s13099-021-00450-4
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spelling doaj-f614db309f344c22aa5625c9c7b52ef32021-08-22T11:18:50ZengBMCGut Pathogens1757-47492021-08-011311810.1186/s13099-021-00450-4Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritisPai-Jui Yeh0Cheng-Tang Chiu1Ming-Wei Lai2Ren-Chin Wu3Chien-Ming Chen4Chia-Jung Kuo5Jun-Te Hsu6Ming-Yao Su7Wei-Pin Lin8Tsung-Hsing Chen9Puo-Hsien Le10Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Pathology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Medical Imaging and Interventions, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of General Surgery, Chang Gung Memorial Hospital, Linkou BranchTaiwan Association of the Study of Small Intestinal DiseaseDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou BranchAbstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided into CMV and non-CMV groups according to immunohistochemistry staining results. The risk factors, clinical presentations, endoscopic features, treatments, outcomes, and prognostic factors of CMV enteritis were then analyzed. Results Forty-two patients (18 CMV, 24 non-CMV group) were included in the study. Major clinical presentations in the CMV group included gastrointestinal bleeding (72.2%), abdominal pain (55.6%), and fever (33.3%); ulcers (72.2%) were the most common endoscopic findings. In-hospital and overall mortality rates were 27.8% and 38.9%, respectively; and longer hospital stays and higher overall mortality rates were observed. Radiotherapy and C-reactive protein levels were prognostic factors for in-hospital mortality. The risk factors for CMV enteritis included immunocompromised status (p = 0.013), steroid use (p = 0.014), shock (p = 0.031), concurrent pneumonia (p = 0.01), antibiotic exposure (p < 0.001), radiotherapy (p = 0.027), chronic kidney disease (p = 0.041), and CMV colitis (p = 0.031). Conclusions Physicians should pay attention to the characteristics of CMV enteritis in high-risk patients to make an early diagnosis and potentially improve the clinical outcome.https://doi.org/10.1186/s13099-021-00450-4Cytomegalovirus enteritisEndoscopyRisk factorPrognostic factorImmunohistochemistry staining
collection DOAJ
language English
format Article
sources DOAJ
author Pai-Jui Yeh
Cheng-Tang Chiu
Ming-Wei Lai
Ren-Chin Wu
Chien-Ming Chen
Chia-Jung Kuo
Jun-Te Hsu
Ming-Yao Su
Wei-Pin Lin
Tsung-Hsing Chen
Puo-Hsien Le
spellingShingle Pai-Jui Yeh
Cheng-Tang Chiu
Ming-Wei Lai
Ren-Chin Wu
Chien-Ming Chen
Chia-Jung Kuo
Jun-Te Hsu
Ming-Yao Su
Wei-Pin Lin
Tsung-Hsing Chen
Puo-Hsien Le
Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
Gut Pathogens
Cytomegalovirus enteritis
Endoscopy
Risk factor
Prognostic factor
Immunohistochemistry staining
author_facet Pai-Jui Yeh
Cheng-Tang Chiu
Ming-Wei Lai
Ren-Chin Wu
Chien-Ming Chen
Chia-Jung Kuo
Jun-Te Hsu
Ming-Yao Su
Wei-Pin Lin
Tsung-Hsing Chen
Puo-Hsien Le
author_sort Pai-Jui Yeh
title Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
title_short Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
title_full Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
title_fullStr Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
title_full_unstemmed Clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
title_sort clinical manifestations, risk factors, and prognostic factors of cytomegalovirus enteritis
publisher BMC
series Gut Pathogens
issn 1757-4749
publishDate 2021-08-01
description Abstract Background To comprehensively analyze the risk factors, clinical characteristics, outcomes, and prognostic factors of Cytomegalovirus (CMV) enteritis. Methods This retrospective cohort study enrolled patients who had undergone pathological examinations for CMV enteritis. They were divided into CMV and non-CMV groups according to immunohistochemistry staining results. The risk factors, clinical presentations, endoscopic features, treatments, outcomes, and prognostic factors of CMV enteritis were then analyzed. Results Forty-two patients (18 CMV, 24 non-CMV group) were included in the study. Major clinical presentations in the CMV group included gastrointestinal bleeding (72.2%), abdominal pain (55.6%), and fever (33.3%); ulcers (72.2%) were the most common endoscopic findings. In-hospital and overall mortality rates were 27.8% and 38.9%, respectively; and longer hospital stays and higher overall mortality rates were observed. Radiotherapy and C-reactive protein levels were prognostic factors for in-hospital mortality. The risk factors for CMV enteritis included immunocompromised status (p = 0.013), steroid use (p = 0.014), shock (p = 0.031), concurrent pneumonia (p = 0.01), antibiotic exposure (p < 0.001), radiotherapy (p = 0.027), chronic kidney disease (p = 0.041), and CMV colitis (p = 0.031). Conclusions Physicians should pay attention to the characteristics of CMV enteritis in high-risk patients to make an early diagnosis and potentially improve the clinical outcome.
topic Cytomegalovirus enteritis
Endoscopy
Risk factor
Prognostic factor
Immunohistochemistry staining
url https://doi.org/10.1186/s13099-021-00450-4
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