Activity of Estafietin and Analogues on <i>Trypanosoma cruzi</i> and <i>Leishmania braziliensis</i>

Activity of Estafietin and Analogues on <i>Trypanosoma cruzi</i> and <i>Leishmania braziliensis</i>

Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of biological activities, including antiprotozoal activity and are considered interesting structures for drug discovery. Four derivatives were synthes...

Full description

Bibliographic Details
Main Authors:	Valeria P. Sülsen, Emilio F. Lizarraga, Orlando G. Elso, Natacha Cerny, Andrés Sanchez Alberti, Augusto E. Bivona, Emilio L. Malchiodi, Silvia I. Cazorla, César A. N. Catalán
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Molecules
Subjects:	sesquiterpene lactones <i>Stevia alpina</i> <i>Trypanosoma cruzi</i> <i>Leishmania braziliensis</i>
Online Access:	https://www.mdpi.com/1420-3049/24/7/1209

Similar Items

Trypanocidal Activity of Four Sesquiterpene Lactones Isolated from Asteraceae Species
by: Orlando G. Elso, et al.
Published: (2020-04-01)

<i>Stevia</i> Genus: Phytochemistry and Biological Activities Update
by: Jimena Borgo, et al.
Published: (2021-05-01)

Antifungal Activity of the Sesquiterpene Lactones from <i>Psephellus bellus</i>
by: Joanna Nawrot, et al.
Published: (2021-06-01)

Sedative Effects of Latexes Obtained from Some <i>Lactuca</i> L. Species Growing in Turkey
by: Selen Ilgün, et al.
Published: (2020-03-01)

Involvement of Allelopathy in the Invasive Potential of <i>Tithonia diversifolia</i>
by: Hisashi Kato-Noguchi
Published: (2020-06-01)

2α-Hydroxyeudesma-4,11(13)-Dien-8β,12-Olide Isolated from <i>Inula britannica</i> Induces Apoptosis in Diffuse Large B-cell Lymphoma Cells
by: Dae Kil Jang, et al.
Published: (2020-02-01)

<i>Stevia Eupatoria</i> and <i>Stevia Pilosa</i> Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells
by: Elizabeth Martínez-Rojo, et al.
Published: (2020-02-01)

Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of <i>Anvillea garcinii</i>
by: Shagufta Perveen, et al.
Published: (2020-04-01)

Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action
by: María Elena Sánchez-Mendoza, et al.
Published: (2020-05-01)

In Vitro Anti-Leishmanial Effect of Metallic Meso-Substituted Porphyrin Derivatives against <i>Leishmania braziliensis and Leishmania panamensis</i> Promastigotes Properties
by: Fabian Espitia-Almeida, et al.
Published: (2020-04-01)

Biologically Active Compounds in <i>Stizolophus balsamita</i> Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters
by: Joanna Nawrot, et al.
Published: (2021-04-01)

Yield and Chemical Composition of Raw Material from Meadow Arnica (<i>Arnica chamissonis</i> Less.) Depending on Soil Conditions and Nitrogen Fertilization
by: Katarzyna Olesińska, et al.
Published: (2021-08-01)

Identification and Functional Characterization of Tissue-Specific Terpene Synthases in <i>Stevia rebaudiana</i>
by: Savitha Dhandapani, et al.
Published: (2020-11-01)

<i>Inula</i> L. Secondary Metabolites against Oxidative Stress-Related Human Diseases
by: Wilson R. Tavares, et al.
Published: (2019-05-01)

Response of ascorbate-glutathione cycle in wild <i>Arabis alpina</i> L. to soil Cd and Pb stress
by: LIU Mei, et al.
Published: (2021-07-01)

Cyclonerane Derivatives from the Algicolous Endophytic Fungus <i>Trichoderma asperellum</i> A-YMD-9-2
by: Yin-Ping Song, et al.
Published: (2019-04-01)

Natural Sesquiterpene Lactones of the 4,15-<i>iso</i>-Atriplicolide Type are Inhibitors of Trypanothione Reductase
by: Mairin Lenz, et al.
Published: (2019-10-01)

The Sesquiterpene Synthase PtTPS5 Produces (1<i>S</i>,5<i>S</i>,7<i>R</i>,10<i>R</i>)-Guaia-4(15)-en-11-ol and (1<i>S</i>,7<i>R</i>,10<i>R</i>)-Guaia-4-en-11-ol in Oomycete-Infected Poplar Roots
by: Nathalie D. Lackus, et al.
Published: (2021-01-01)

Chemical Defense of Yacón (<i>Smallanthus sonchifolius</i>) Leaves against Phytophagous Insects: Insect Antifeedants from Yacón Leaf Trichomes
by: Kaisei Tsunaki, et al.
Published: (2020-07-01)

Atypical Lindenane-Type Sesquiterpenes from <i>Lindera myrrha</i>
by: Thuc-Huy Duong, et al.
Published: (2020-04-01)

Sesquiterpene Lactones from <i>Cotula cinerea</i> with Antibiotic Activity against Clinical Isolates of <i>Enterococcus faecalis</i>
by: Alessio Cimmino, et al.
Published: (2021-07-01)

<i>Premna</i> Species in Vietnam: Essential Oil Compositions and Mosquito Larvicidal Activities
by: Nguyen Huy Hung, et al.
Published: (2020-08-01)

Natural Variation in Adventitious Rooting in the Alpine Perennial <i>Arabis alpina</i>
by: Priyanka Mishra, et al.
Published: (2020-02-01)

Sesquiterpene Lactones and Flavonoids from <i>Psephellus pyrrhoblepharus</i> with Antiproliferative Activity on Human Gynecological Cancer Cell Lines
by: Pelin Tastan, et al.
Published: (2019-08-01)

Arbuscular Mycorrhizal Fungi Colonization Promotes Changes in the Volatile Compounds and Enzymatic Activity of Lipoxygenase and Phenylalanine Ammonia Lyase in <i>Piper nigrum</i> L. ‘Bragantina’
by: Rafaela da Trindade, et al.
Published: (2019-10-01)

Characterization of the Antinociceptive Activity from <i>Stevia serrata</i> Cav
by: Millena S. Cordeiro, et al.
Published: (2020-04-01)

Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian <i>Eryngium campestre</i>
by: Ali Medbouhi, et al.
Published: (2018-12-01)

Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from <i>Artemisia argyi</i> Associated Endophytic <i>Trichoderma virens</i> QA-8
by: Xiao-Shan Shi, et al.
Published: (2021-02-01)

A Review on Phytochemicals of the Genus <i>Maytenus</i> and Their Bioactive Studies
by: Yuan-Yuan Huang, et al.
Published: (2021-07-01)

<i>Quorum Sensing</i> Regulation in Phytopathogenic Bacteria
by: Julie Baltenneck, et al.
Published: (2021-01-01)

Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant <i>Myoporum bontioides</i> A. Gray
by: Li-Mei Dong, et al.
Published: (2018-11-01)

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity
by: Njogu M. Kimani, et al.
Published: (2019-06-01)

Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls
by: María Elena Sánchez-Mendoza, et al.
Published: (2019-02-01)

Identification of Quorum-Sensing Molecules of <i>N</i>-Acyl-Homoserine Lactone in <i>Gluconacetobacter</i> Strains by Liquid Chromatography-Tandem Mass Spectrometry
by: Ling-Pu Liu, et al.
Published: (2019-07-01)

Quorum Quenching in a Novel <i>Acinetobacter</i> sp. XN-10 Bacterial Strain against <i>Pectobacterium carotovorum</i> subsp. <i>carotovorum</i>
by: Wenping Zhang, et al.
Published: (2020-07-01)

Comparative Assessment of the Basic Chemical Composition and Antioxidant Activity of <i>Stevia rebaudiana</i> Bertoni Dried Leaves, Grown in Poland, Paraguay and Brazil—Preliminary Results
by: Teresa Leszczyńska, et al.
Published: (2021-04-01)

Sesquiterpene Lactones from <i>Calea pinnatifida</i>: Absolute Configuration and Structural Requirements for Antitumor Activity
by: Lhaís Araújo Caldas, et al.
Published: (2020-06-01)

New Cadinane Sesquiterpenes from the Stems of <i>Kadsura heteroclita</i>
by: Liang Cao, et al.
Published: (2019-04-01)

Farnesane-Type Sesquiterpenoids with Antibiotic Activity from <i>Chiliadenus lopadusanus</i>
by: Marco Masi, et al.
Published: (2021-02-01)

Application of CRISPR/Cas9-Based Reverse Genetics in <i>Leishmania braziliensis</i>: Conserved Roles for HSP100 and HSP23
by: Vanessa Adaui, et al.
Published: (2020-09-01)