CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth

CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth

CD47 is a glycoprotein of the immunoglobulin superfamily that is often overexpressed in different types of hematological and solid cancer tumors and plays important role in blocking phagocytosis, increased tumor survival, metastasis and angiogenesis. In the present report, we designed CAR (chimeric...

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Bibliographic Details
Main Authors: Vita Golubovskaya, Robert Berahovich, Hua Zhou, Shirley Xu, Hizkia Harto, Le Li, Cheng-Chi Chao, Mike Ming Mao, Lijun Wu
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Cancers
Subjects:
chimeric antigen receptor (CAR)
cell therapy
immunotherapy
CD47 tumor antigen
humanized antibody
Online Access:https://www.mdpi.com/2072-6694/9/10/139

Internet

https://www.mdpi.com/2072-6694/9/10/139

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