Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN

Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN

Bisphenol A (BPA) is widely distributed in the environment and human surroundings and is closely related to the occurrence of many chronic diseases including female infertility. Although BPA-induced granulosa cell apoptosis has been widely reported, the underlying mechanisms remain unknown. In this...

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Bibliographic Details
Main Authors: Mingquan Huang, Meizhou Huang, Xingjie Li, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Bisphenol A
Apoptosis
Granulosa cells
Oxidative stress
Estrogen receptor
Calcium ion accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320312665

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