Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning

Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning

We present the analysis of the defective genetic pathways of the Late-Onset Alzheimer’s Disease (LOAD) compared to the Mild Cognitive Impairment (MCI) and Healthy Controls (HC) using different sampling methodologies. These algorithms sample the uncertainty space that is intrinsic to any kind of high...

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Bibliographic Details
Main Authors: Juan Luis Fernández-Martínez, Óscar Álvarez-Machancoses, Enrique J. de Andrés-Galiana, Guillermina Bea, Andrzej Kloczkowski
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s Disease
Mild Cognitive Impairment
Pathway analysis
Deep Pathways Sampling
Drug repositioning
Online Access:https://www.mdpi.com/1422-0067/21/10/3594

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