A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries
Background and Aims: Desflurane and sevoflurane are inhalational anesthetics which provide stable intraoperative hemodynamics and rapid emergence from anesthesia. Dexmedetomidine is an α2-agonist with sedative and hypnotic effects. We compared recovery following anesthesia with a combination of a co...
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doaj-f6084bbf143e419e8b7a91cda0297e552020-11-25T01:42:00ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852017-01-0133452452810.4103/joacp.JOACP_61_16A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeriesYogita PatilSuyog BagadeNilesh PatilNalini JadhavBackground and Aims: Desflurane and sevoflurane are inhalational anesthetics which provide stable intraoperative hemodynamics and rapid emergence from anesthesia. Dexmedetomidine is an α2-agonist with sedative and hypnotic effects. We compared recovery following anesthesia with a combination of a continuous intravenous infusion of dexmedetomidine and desflurane or sevoflurane in cases of spine surgeries because no such data are available from India. Material and Methods: It was a single-blind, prospective, randomized study. After institutional ethics committee approval, patients were randomly allocated to one of the two groups of fifty patients each. Group D received desflurane and Group S received sevoflurane, along with dexmedetomidine 0.5 μg/kg/h IV infusion for maintenance of anesthesia. Results and Conclusions: Extubation time (ET) in Group D was shorter by 4.2 min than in Group S (10.1 ± 2.2 and 14.2 ± 1.3; P = 0.004). Postoperative recovery, postoperative analgesic, and antiemetic requirement between the groups were comparable The mean dial setting required to maintain the minimum alveolar concentration of 1 intraoperatively was 3.1 for desflurane and 0.7 for sevoflurane.http://www.joacp.org/article.asp?issn=0970-9185;year=2017;volume=33;issue=4;spage=524;epage=528;aulast=PatilDesfluranedial settingextubation timeminimum alveolar concentrationpostoperative recoverysevoflurane |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yogita Patil Suyog Bagade Nilesh Patil Nalini Jadhav |
spellingShingle |
Yogita Patil Suyog Bagade Nilesh Patil Nalini Jadhav A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries Journal of Anaesthesiology Clinical Pharmacology Desflurane dial setting extubation time minimum alveolar concentration postoperative recovery sevoflurane |
author_facet |
Yogita Patil Suyog Bagade Nilesh Patil Nalini Jadhav |
author_sort |
Yogita Patil |
title |
A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
title_short |
A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
title_full |
A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
title_fullStr |
A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
title_full_unstemmed |
A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
title_sort |
prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Anaesthesiology Clinical Pharmacology |
issn |
0970-9185 |
publishDate |
2017-01-01 |
description |
Background and Aims: Desflurane and sevoflurane are inhalational anesthetics which provide stable intraoperative hemodynamics and rapid emergence from anesthesia. Dexmedetomidine is an α2-agonist with sedative and hypnotic effects. We compared recovery following anesthesia with a combination of a continuous intravenous infusion of dexmedetomidine and desflurane or sevoflurane in cases of spine surgeries because no such data are available from India.
Material and Methods: It was a single-blind, prospective, randomized study. After institutional ethics committee approval, patients were randomly allocated to one of the two groups of fifty patients each. Group D received desflurane and Group S received sevoflurane, along with dexmedetomidine 0.5 μg/kg/h IV infusion for maintenance of anesthesia.
Results and Conclusions: Extubation time (ET) in Group D was shorter by 4.2 min than in Group S (10.1 ± 2.2 and 14.2 ± 1.3; P = 0.004). Postoperative recovery, postoperative analgesic, and antiemetic requirement between the groups were comparable The mean dial setting required to maintain the minimum alveolar concentration of 1 intraoperatively was 3.1 for desflurane and 0.7 for sevoflurane. |
topic |
Desflurane dial setting extubation time minimum alveolar concentration postoperative recovery sevoflurane |
url |
http://www.joacp.org/article.asp?issn=0970-9185;year=2017;volume=33;issue=4;spage=524;epage=528;aulast=Patil |
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