Corticosteroids augment BRAF inhibitor vemurafenib induced lymphopenia and risk of infection.

Corticosteroids augment BRAF inhibitor vemurafenib induced lymphopenia and risk of infection.

We have previously demonstrated an impact of the BRAF inhibitor vemurafenib on patient lymphocyte counts. In the current study, the extent to which concomitant use of corticosteroids in BRAF inhibitor treated patients affects lymphocyte counts and predisposes to infection was investigated. A cohort...

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Main Authors: Wiebke Sondermann, Klaus G Griewank, Bastian Schilling, Elisabeth Livingstone, Julia C Leyh, Natalia Rompoti, Ioana Cosgarea, Tobias Schimming, Dirk Schadendorf, Lisa Zimmer, Uwe Hillen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4405567?pdf=render

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