Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking is Associated with Distinct Neuroadaptations in the Dentate Gyrus

Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking is Associated with Distinct Neuroadaptations in the Dentate Gyrus

The present study examined differences in operant responses in adult male and female rats during distinct phases of addiction. Males and females demonstrated escalation in methamphetamine (0.05 mg/kg, i.v.) intake with females showing enhanced latency to escalate, and bingeing. Following protracted...

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Bibliographic Details
Main Authors: Yoshio Takashima, Joyee Tseng, McKenzie J. Fannon, Dvijen C. Purohit, Leon W. Quach, Michael J. Terranova, Khush M. Kharidia, Robert J. Oliver, Chitra D. Mandyam
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Brain Sciences
Subjects:
granule cell neurons
electrophysiology
GluN
CaMKII
choline acetyltransferase
Online Access:https://www.mdpi.com/2076-3425/8/12/208

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