Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis, cancer, etc. In this study, we provide the firs...

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Bibliographic Details
Main Authors: Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei, Feng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
morphine tolerance
endoplasmic reticulum stress
unfolded protein response
binding immunoglobulin protein
activating transcription factor 6
protein kinase RNA-like ER kinase
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00072/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2018.00072/full

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