Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia

Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia

Effects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blo...

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Bibliographic Details
Main Authors: Yoshiaki Ohishi, Tomoya Matsutomi, Taixing Zheng, Jun-ichi Kakimura, Hiroshi Maruyama, Nobukuni Ogata
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319326623

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