Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia

Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia

Effects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blo...

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Main Authors: Yoshiaki Ohishi, Tomoya Matsutomi, Taixing Zheng, Jun-ichi Kakimura, Hiroshi Maruyama, Nobukuni Ogata
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319326623
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spelling doaj-f5f7e8bdf2cd4d43b1e921dee01c387f2020-11-25T01:27:47ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01923296300Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root GangliaYoshiaki Ohishi0Tomoya Matsutomi1Taixing Zheng2Jun-ichi Kakimura3Hiroshi Maruyama4Nobukuni Ogata5Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanEffects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blocking action of 4-AP may be attenuated by membrane depolarization. When two IAs were evoked with variable intervals, the peak amplitude of the IA induced by the second pulse was augmented in the presence of 4-AP. These results indicate that the action of 4-AP can be modulated by concurrent neuronal activities.http://www.sciencedirect.com/science/article/pii/S1347861319326623
collection DOAJ
language English
format Article
sources DOAJ
author Yoshiaki Ohishi
Tomoya Matsutomi
Taixing Zheng
Jun-ichi Kakimura
Hiroshi Maruyama
Nobukuni Ogata
spellingShingle Yoshiaki Ohishi
Tomoya Matsutomi
Taixing Zheng
Jun-ichi Kakimura
Hiroshi Maruyama
Nobukuni Ogata
Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
Journal of Pharmacological Sciences
author_facet Yoshiaki Ohishi
Tomoya Matsutomi
Taixing Zheng
Jun-ichi Kakimura
Hiroshi Maruyama
Nobukuni Ogata
author_sort Yoshiaki Ohishi
title Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
title_short Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
title_full Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
title_fullStr Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
title_full_unstemmed Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia
title_sort use-dependent removal of the 4-aminopyridine-induced block of the transient k+ current in rat dorsal root ganglia
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2003-01-01
description Effects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blocking action of 4-AP may be attenuated by membrane depolarization. When two IAs were evoked with variable intervals, the peak amplitude of the IA induced by the second pulse was augmented in the presence of 4-AP. These results indicate that the action of 4-AP can be modulated by concurrent neuronal activities.
url http://www.sciencedirect.com/science/article/pii/S1347861319326623
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AT taixingzheng usedependentremovalofthe4aminopyridineinducedblockofthetransientkcurrentinratdorsalrootganglia
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