Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other <i>Coronaviridae</i>...

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Bibliographic Details
Main Authors: Daniele Focosi, Angelo Genoni, Ersilia Lucenteforte, Silvia Tillati, Antonio Tamborini, Pietro Giorgio Spezia, Lorenzo Azzi, Andreina Baj, Fabrizio Maggi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Life
Subjects:
COVID-19
SARS-CoV-2
convalescent plasma
neutralizing antibody
NL63
229E
Online Access:https://www.mdpi.com/2075-1729/11/4/298

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