LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

Bibliographic Details
Main Authors:	Changhao Chen, Wang He, Jian Huang, Bo Wang, Hui Li, Qingqing Cai, Feng Su, Junming Bi, Hongwei Liu, Bin Zhang, Ning Jiang, Guangzheng Zhong, Yue Zhao, Wen Dong, Tianxin Lin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06152-x

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spelling	doaj-f5d2240101054e48aeea263d84e7d95f2021-05-11T09:29:52ZengNature Publishing GroupNature Communications2041-17232018-09-019111810.1038/s41467-018-06152-xLNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitmentChanghao Chen0Wang He1Jian Huang2Bo Wang3Hui Li4Qingqing Cai5Feng Su6Junming Bi7Hongwei Liu8Bin Zhang9Ning Jiang10Guangzheng Zhong11Yue Zhao12Wen Dong13Tianxin Lin14Department of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of VirginiaDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South ChinaDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Tumor Intervention, Sun Yat-sen University First Affiliated HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalDepartment of Urology, State key Laboratory of Oncology in South China, Sun Yat-sen Memorial HospitalMechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.https://doi.org/10.1038/s41467-018-06152-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin
spellingShingle	Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment Nature Communications
author_facet	Changhao Chen Wang He Jian Huang Bo Wang Hui Li Qingqing Cai Feng Su Junming Bi Hongwei Liu Bin Zhang Ning Jiang Guangzheng Zhong Yue Zhao Wen Dong Tianxin Lin
author_sort	Changhao Chen
title	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_short	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_full	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_fullStr	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_full_unstemmed	LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
title_sort	lnmat1 promotes lymphatic metastasis of bladder cancer via ccl2 dependent macrophage recruitment
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.
url	https://doi.org/10.1038/s41467-018-06152-x
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LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

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