Cytosolic HMGB1 Expression in Human Renal Clear Cell Cancer Indicates Higher Pathological T Classifications and Tumor Grades

Cytosolic HMGB1 Expression in Human Renal Clear Cell Cancer Indicates Higher Pathological T Classifications and Tumor Grades

Purpose: High mobility group box (HMGB) proteins are nuclear nonhistone chromosomalproteins that bend DNA, bind preferentially to distorted DNA structures, and promote the assemblyof site-specific DNA binding proteins. Recent reports indicate that HMGB1 functionsas a proinflammatory cytokine. Here,...

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Bibliographic Details
Main Authors: Koji Mikami, Yuta Takeshima, Masayoshi Zaitsu, Akiko Tonooka, Koichi Sakazume, Takumi Takeuchi, Toshimasa Uekusa
Format: Article
Language:English
Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2013-09-01
Series:Urology Journal
Subjects:
kidney neoplasms
gene expression
HMGB1 protein
genetics
neoplasm invasiveness
Online Access:http://www.urologyjournal.org/index.php/uj/article/view/1425/749

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