Postnatal Growth Restriction in Mice Alters Cardiac Protein Composition and Leads to Functional Impairment in Adulthood

Postnatal Growth Restriction in Mice Alters Cardiac Protein Composition and Leads to Functional Impairment in Adulthood

Postnatal growth restriction (PGR) increases the risk for cardiovascular disease (CVD) in adulthood, yet there is minimal mechanistic rationale for the observed pathology. The purpose of this study was to identify proteomic differences in hearts of growth-restricted and unrestricted mice, and propos...

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Bibliographic Details
Main Authors: Joseph R. Visker, Lawrence J. Dangott, Eric C. Leszczynski, David P. Ferguson
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
DOHaD
postnatal growth restriction
cardiac function
p57<sup>kip2</sup>
titin
collagen
Online Access:https://www.mdpi.com/1422-0067/21/24/9459

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