Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
Background. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of p...
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doaj-f5bb5b97fe2145aa9939e248de077a332021-05-17T00:00:15ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/9678363Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC ComponentZiyu Zhu0Jialiang Gao1Zhixin Liu2Chunfeng Li3Yingwei Xue4Department of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryDepartment of GynecologyDepartment of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryBackground. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Methods. A total of 336 MGC were enrolled in this study, and the characteristics of the tumor, including pathological features and clinical data, were retrospectively analyzed. Results. A high PLR was associated with larger tumor size, advanced tumor invasion, lymph node metastasis, advanced TNM stage, tumor location, total gastrectomy, low hemoglobin level, low albumin level, high fibrinogen level, high platelet level, and high neutrophil-to-lymphocyte ratio (NLR, all P′s<0.05). Multivariate analysis identified age (HR=1.876; 95% CI 1.361-2.585, P<0.001), TNM stage (HR=2.350; 95% CI 1.216-4.542, P=0.011), globulin (HR=1.520; 95% CI 1.067-2.165, P=0.020), total gastrectomy (HR=0.537; 95% CI 0.373-0.772, P=0.001), and PLR (HR=1.582; 95% CI 1.066-2.348, P=0.023) as independent prognostic factors for OS. Conclusion. Preoperative PLR is related to pathological features and may independently evaluate the survival of MGC. Therefore, preoperative PLR may help physicians develop treatment plans and evaluate survival in these patients.http://dx.doi.org/10.1155/2021/9678363 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ziyu Zhu Jialiang Gao Zhixin Liu Chunfeng Li Yingwei Xue |
spellingShingle |
Ziyu Zhu Jialiang Gao Zhixin Liu Chunfeng Li Yingwei Xue Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component BioMed Research International |
author_facet |
Ziyu Zhu Jialiang Gao Zhixin Liu Chunfeng Li Yingwei Xue |
author_sort |
Ziyu Zhu |
title |
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component |
title_short |
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component |
title_full |
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component |
title_fullStr |
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component |
title_full_unstemmed |
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component |
title_sort |
preoperative platelet-to-lymphocyte ratio (plr) for predicting the survival of stage i-iii gastric cancer patients with a mgc component |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6141 |
publishDate |
2021-01-01 |
description |
Background. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Methods. A total of 336 MGC were enrolled in this study, and the characteristics of the tumor, including pathological features and clinical data, were retrospectively analyzed. Results. A high PLR was associated with larger tumor size, advanced tumor invasion, lymph node metastasis, advanced TNM stage, tumor location, total gastrectomy, low hemoglobin level, low albumin level, high fibrinogen level, high platelet level, and high neutrophil-to-lymphocyte ratio (NLR, all P′s<0.05). Multivariate analysis identified age (HR=1.876; 95% CI 1.361-2.585, P<0.001), TNM stage (HR=2.350; 95% CI 1.216-4.542, P=0.011), globulin (HR=1.520; 95% CI 1.067-2.165, P=0.020), total gastrectomy (HR=0.537; 95% CI 0.373-0.772, P=0.001), and PLR (HR=1.582; 95% CI 1.066-2.348, P=0.023) as independent prognostic factors for OS. Conclusion. Preoperative PLR is related to pathological features and may independently evaluate the survival of MGC. Therefore, preoperative PLR may help physicians develop treatment plans and evaluate survival in these patients. |
url |
http://dx.doi.org/10.1155/2021/9678363 |
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