Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component

Background. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of p...

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Main Authors: Ziyu Zhu, Jialiang Gao, Zhixin Liu, Chunfeng Li, Yingwei Xue
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2021/9678363
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spelling doaj-f5bb5b97fe2145aa9939e248de077a332021-05-17T00:00:15ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/9678363Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC ComponentZiyu Zhu0Jialiang Gao1Zhixin Liu2Chunfeng Li3Yingwei Xue4Department of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryDepartment of GynecologyDepartment of Gastrointestinal SurgeryDepartment of Gastrointestinal SurgeryBackground. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Methods. A total of 336 MGC were enrolled in this study, and the characteristics of the tumor, including pathological features and clinical data, were retrospectively analyzed. Results. A high PLR was associated with larger tumor size, advanced tumor invasion, lymph node metastasis, advanced TNM stage, tumor location, total gastrectomy, low hemoglobin level, low albumin level, high fibrinogen level, high platelet level, and high neutrophil-to-lymphocyte ratio (NLR, all P′s<0.05). Multivariate analysis identified age (HR=1.876; 95% CI 1.361-2.585, P<0.001), TNM stage (HR=2.350; 95% CI 1.216-4.542, P=0.011), globulin (HR=1.520; 95% CI 1.067-2.165, P=0.020), total gastrectomy (HR=0.537; 95% CI 0.373-0.772, P=0.001), and PLR (HR=1.582; 95% CI 1.066-2.348, P=0.023) as independent prognostic factors for OS. Conclusion. Preoperative PLR is related to pathological features and may independently evaluate the survival of MGC. Therefore, preoperative PLR may help physicians develop treatment plans and evaluate survival in these patients.http://dx.doi.org/10.1155/2021/9678363
collection DOAJ
language English
format Article
sources DOAJ
author Ziyu Zhu
Jialiang Gao
Zhixin Liu
Chunfeng Li
Yingwei Xue
spellingShingle Ziyu Zhu
Jialiang Gao
Zhixin Liu
Chunfeng Li
Yingwei Xue
Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
BioMed Research International
author_facet Ziyu Zhu
Jialiang Gao
Zhixin Liu
Chunfeng Li
Yingwei Xue
author_sort Ziyu Zhu
title Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
title_short Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
title_full Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
title_fullStr Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
title_full_unstemmed Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component
title_sort preoperative platelet-to-lymphocyte ratio (plr) for predicting the survival of stage i-iii gastric cancer patients with a mgc component
publisher Hindawi Limited
series BioMed Research International
issn 2314-6141
publishDate 2021-01-01
description Background. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Methods. A total of 336 MGC were enrolled in this study, and the characteristics of the tumor, including pathological features and clinical data, were retrospectively analyzed. Results. A high PLR was associated with larger tumor size, advanced tumor invasion, lymph node metastasis, advanced TNM stage, tumor location, total gastrectomy, low hemoglobin level, low albumin level, high fibrinogen level, high platelet level, and high neutrophil-to-lymphocyte ratio (NLR, all P′s<0.05). Multivariate analysis identified age (HR=1.876; 95% CI 1.361-2.585, P<0.001), TNM stage (HR=2.350; 95% CI 1.216-4.542, P=0.011), globulin (HR=1.520; 95% CI 1.067-2.165, P=0.020), total gastrectomy (HR=0.537; 95% CI 0.373-0.772, P=0.001), and PLR (HR=1.582; 95% CI 1.066-2.348, P=0.023) as independent prognostic factors for OS. Conclusion. Preoperative PLR is related to pathological features and may independently evaluate the survival of MGC. Therefore, preoperative PLR may help physicians develop treatment plans and evaluate survival in these patients.
url http://dx.doi.org/10.1155/2021/9678363
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